ABSTRACT
Introduction: More than 1000 suicides occur daily worldwide and suicidal attempts occures 10 to 20 times. Identification of risk factors can lead to design preventive interventions to reduce the incidence of suicide. The aim of this study is to determine the association between suicidal ideations and psychosocial characteristics in depressed patients of Razi Hospital in Tabriz
Methods: This descriptive analytical study was conducted in 2013. 80 depressed patients who have suicidal ideation were selected through convinience sampling method. To collect data, a questionnaire consisting of social and mental questionnaire and Beck suicide ideation scale was used. To analyze data, descriptive and inferential statistics was used
Result: The overall results of this study showed that significant relationship was seen between suicide ideation and dimensions and gender, job, education, history and method of suicidal attempt, physical disorders, using non psychotropic drugs [P<0.05]
Conclusion: Regarding the issue that suicidal ideation is an important risk factor for successful suicide and identification of vulnerble groups have important role in suicide prevention; therefore, According the result of study we suggest that female patients with lower education less than diploma that use psychotropic drugs should be further considered as a risk group
ABSTRACT
Visceral leishmaniasis [VL] is a parasitic disease caused by a protozoan of Leishmania genus and in Iran by Leishmania infantum. The protective immune response against VL is cellular immunity through Th1 CD4+, which dominant chemokiens are IL12, IFN-alpha and IL18 and lead to Th1 response. Single nucleotide polymorphism [SNP] on IL-18 gene and its relation to IL18 levels in blood and IL18 function have been studied in many inflammatory diseases such as Behcect's disease and tuberculosis. According to the important role of IL-18 in immunity against visceral leishmaniasis, this study was conducted to demonstrate the prevalence of genotypes on-607A/C in promoter region of IL-18 gene. This descriptive and cross-sectional study was done on 91 pateints with confirmed VL, 105 healthy sero-negative controls and 78 seropositive controls during 1999-2009. Salting out method was used to extract DNA and ARMS-PCR was used to determine the genotype of-607A/C allele of individuals. Statistical analysis of genotypes was performed using Chi-Square test. According to the results,-607C/C was the dominant genotype among the groups [35.8%]. Distribution of genotypes among groups had not any significant difference. The lowest genotype among healthy sero-positive and patients were-607A/C and-607A/A, respectively. Statistical analysis of distribution of genotypes, did not reveal any significant difference among groups. The dominant genotypes of VL patients, healthy sero-negatives and healthy seropositives were-607C/C [38.5%],-607A/C [37.1%] and-607C/C [35.9%] respectively